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The AGO Study Group is a non-profit organisation with the aim to enhance the therapy of pelvic tumours in women. It developed from the AGO Ovarian Cancer Study Group, which was founded in 1993.
Ovar Primary diseas
AGO-OVAR 1/2

Phase I/II study of the combination of carboplatin and paclitaxel as first-line therapy patients with advanced epithelial ovarian cancer

A. du Bois, H.-J. Lück, T. Bauknecht, V. Möbus, H. Bochtler, K. Diergarten & H.-G. Meerpohl

Annals of Oncology 8: 335-361 (1997)




AGO-OVAR 2.9

Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel an carboplatin for patients with platinum-sensitive ovarian cancer in late relapse

Pujade-Lauraine E, Wagner U, Aavall-Lundqvist E, Gebski V, Heywood M, Vasey P A, Volgger B, Vergote I, Pignata S, Ferrero A, Sehouli J, Lortholary A, Kristensen G, Jackisch C, Joly F, Brown C, Le Fur N, and du Bois A

J Clin Oncol 28:3323-3329, 2010





AGO-OVAR 3

A Randomized Clinical Trial of Cisplatin/Paclitaxel Versus Carboplatin/Paclitaxel as First-Line Treatment of Ovarian Cancer

du Bois A, Lück H.-J, Meier W, Adams H-P, Möbus V, Costa S, Bauknecht T, Richter B, Warm M, Schröder W, Olbricht S, Nitz U, Jackisch C, Emons G, Wagner U, Kuhn W, Pfisterer J, for the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Ovarian Cancer Study Group

J Natl Cancer Inst 2003; 95:1320-30




AGO-OVAR 4

First-line chemotherapy with epirubicin, paclitaxel, and Carboplatin (ET-Carbo) for advanced ovarian carcinoma. A phase I/II study of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Ovarian Cancer Study Group

A du Bois, HJ Lück, T Bauknecht, W Meier, B Richter, J Pfisterer, J Quaas, W Kuhn

J Clin Oncol 17: 46-51, 1999




AGO-OVAR 5

Addition of epirubicin as third drug to carboplatin-paclitaxel in firstline treatment of advanced ovarian cancer. ......

du Bois A, Weber B, Rochon J, Meier W, Goupil A, Olbricht S, Barats Jean-Claude, Kuhn W, Orfeuvre H, Wagner U, Richter B, Lueck HJ, Pfisterer J, Costa S, Schroeder W, Kimmig R, Pujade-Lauraine E for AGO-OVAR and GINECO

J Clin Oncol 24: 1127-1135




AGO-OVAR 6

Docetaxel and carboplatin as first-line chemotherapy in patients with advanced gynecological tumors. A phase I/II trial of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO-OVAR) Ovarian Cancer Study Group

Pfisterer J, du Bois A, Wagner U, Quaas J, Blohmer JU, Wallwiener D and Hilpert F

Gynecologic Oncology 92 (2004) 949-956




AGO-OVAR 7

Randomized Phase III Trial of Topotecan Following Carboplatin and Paclitaxel in First-line Treatment of Advanced Ovarian Cancer: A Gynecologic Cancer Intergroup Trial of the AGO-OVAR and GINECO

Pfisterer J, Weber B, Reuss A, Kimmig R, du Bois A, Wagner U, Bourgeois H, Meier W, Costa S, Blohmer JU, Lortholary A, Olbricht S, Stähle A, Jackisch C, Hardy-Bessard AC, Möbus V, Quaas J, Richter B, Schröder W, Geay JF, Lück HJ, Kuhn W, Meden H, Nitz U, Pujade-Lauraine E for the AGO-OVAR and GINECO

J Natl Cancer Inst 2006; 98:1036-1045




AGO-OVAR 8

A phase II study of paclitaxel, carboplatin, and gemcitabine in previously untreated patients with epithelial ovarian cancer FIGO stage IC-IV (AGO-OVAR protocol OVAR-8)

du Bois A, Belau A, Wagner U, Pfisterer J , Schmalfeldt B, Richter B, Stähle A, Jackisch C, Lueck H-J, Schroeder W, Olbricht S, Elser G and for the Arbeitsgemeinschaft Gyneaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR)

Gynecol Oncol 96 (2005) 444-451




Recurrent diseas
AGO-OVAR 2.1

Chemotherapy versus Hormonal Treatment in Platinum- and Paclitaxel-Refractory Ovarian Cancer: A Randomized Trial of the German Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) Study Group Ovarian Cancer

A du Bois, W Meier, HJ Lück, G Emons, V Möbus, W Schröder, S Costa, T Bauknecht, S Olbricht, C Jackisch, B Richter, U Wagner

Annals of Oncology 13:251-257,2002




AGO-OVAR 2.2

Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR 2.2 trial

The ICON and AGO Collaborators (writing committee)

Lancet 361: 2099-2106 (2003)




AGO-OVAR 2.4

2nd-line chemotherapy with carboplatin and gemcitabine in patients with platinum sensitive recurrent ovarian cancer. A phase I/II study of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) Ovarian Cancer Study Group

A du Bois, HJ Lück, J Pfisterer, W Schroeder, JU Blohmer, R Kimmig, V Moebus, J Quaas

Annals of Oncology 12: 1115-1120, 2001




AGO-OVAR 2.5

Gemcitabine plus carboplatin versus carboplatin in patients with platinum-sensitive-recurrent ovarian cancer

Pfisterer J, Plante M, Vergote I, Zimmerman A, du Bois A, Hirte H, Lacave A J, Wagner U, Stähle A, Stuart G, Kimmig R, Olbricht S, Le T, Emerich J, Kuhn W, Bentley J, Jackisch C, Lück H-J, Rochon J, Zimmermann A H, Eisenhauer E for the AGO OVAR, NCIC CTG and EORTC GCGPfisterer J, Plante M, Vergote I, Zimmerman A, du Bois A, Hirte H, Lacave A J, Wagner U, Stähle A, Stuart G, Kimmig R, Olbricht S, Le T, Emerich J, Kuhn W, Bentley J, Jackisch C, Lück H-J, Rochon J, Zimmermann A H, Eisenhauer E for the AGO OVAR, NCIC CTG and EORTC GCG

J Clin Oncol 24:4699-4707, 2006




AGO-OVAR 2.6

Gefitinib in combination with tamoxifen in patients with ovarian cancer refractory or resistant to platinum-taxane based therapy – A phase II trial of the AGO Ovarian Cancer Study Group (AGO-OVAR 2.6)

Wagner U, du Bois A, Pfisterer J, Huober J, Loibl S, Lück HJ, Sehouli J, Gropp M, Stähle A, Schmalfeldt, B, Meier W, Jackisch C

Gynecol Oncol 2007; 105:132-137




AGO-OVAR 2.8

The anti-idiotypic antibody abagovomab in patients with recurrent ovarian cancer - A phase I trial of the AGO-OVAR

Pfisterer J, du Bois A, Sehouli J, Loibl S, Reinartz S, Reuß A, Canzler U, Belau A, Jackisch C, Kimmig R, Wollschlaeger K, Heilmann V, Hilpert , On behalf of the AGO-OVAR

Ann Oncol 17: 1568-1577, 2006




Uterus
AGO GYN 2

Pegylated liposomal doxorubicin and carboplatin in advanced gynecologic tumors: a prospective phase I/II study of the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR)

A. du Bois, A. Burges, W. Meier, J. Pfisterer, B. Schmalfeldt, B. Richter, C. Jackisch, A. Staehle, R. Kimmig & G. Elser on behalf of AGO-OVAR Germany

Annals of Oncology 17: 93-96, 2006




AGO GYN 3

Combination Therapy with Pegylated Liposomal Doxorubicin and Carboplatin in Gynecologic Malignancies: A Prospective Phase-II Study of the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and Kommission Uterus (AGO-K-Ut)

du Bois A, Pfisterer J, Burchardi N, Loibl S, Huober J, Wimberger P, Burges A, Staehle A, Jackisch C, Koelbl H

Gynecol Oncol 2007; 107: 518-525




AGO GYN 4

A Phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignancies

du Bois A, Huober J, Stopfer P, Pfisterer J, Wimberger P, Loibl S Reichardt V, Harter P

Annals of Oncol 2010 21:370-375




Clinical trials in surgical settings
AGO-OVAR OP.1/DESKTOP I

Surgery in recurrent ovarian cancer - The Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) DESKTOP OVAR trial

Harter P, du Bois A, Hahmann M, Hasenburg A, Burges A, Loibl S, Gropp M, Huober J, Fink D, Schröder W, Muenstedt K, Schmalfeldt B, Emons G, Pfisterer J, Wollschlaeger K, Meerpohl HG, Breitbach GP, Tanner B, Sehouli J. Heilmann V for the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Committee (AGO OC) and the AGO Ovarian Cancer Study Group (AGO-OVAR)

Ann Surg Oncol 2006 online first 10-2006




Other publications
Advanced epithelial ovarian cancer: 1998 consensus statement

J.S. Berek, K. Bertelsen, A. du Bois, M.F. Brady, J. Carmichel, E.A. Eisenhauer, M. Gore, S. Grenman, T.C. Hamilton, S. W. Hansen, P.G. Harper, G. Horvath, S.B. Kaye, H.J. Lück, B. Lund, W.P. McGuire, J.P. Neijt, R.F. Ozols, M.K.B. Parmar, M.J. Piccart-Gebhart, R. van Rijswijk, P. Rosenberg, G.J.S. Rustin, C. Sessa, J.T. Thigpen, C. Tropé, M.K. Tuxen, I. Vergote, J.B. Vermorken, & P.H.B. Willemse

Ann Oncol 10 (suppl. 1): S87-S92 (1999)




Ist eine effiziente klinische Forschung in der gynäkologischen Onkologie in Deutschland möglich? Historie und aktueller Stand am Beispiel der AGO-Ovarialkarzinom-Studien. Eine Stellungnahme der AGO Studiengruppe Ovarialkarzinom

du Bois A, Studiengruppe Ovarialkarzinom der Arbeitsgemeinschaft gynäkologische Onkologie (AGO)

Forum DKG 14: 815-824 (1999)




Incidence of Venous Thromboembolism in Patients With Ovarian Cancer Undergoing Platinum/Paclitaxel-Containing First-Line Chemotherapie: An Exploratory Analysis by the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group

Christina Fotopoulou, Andreas du Bois, Alexandros N. Karavas, Ralf Trappe, Behnaz Aminossadati, Barbara Schmalfeldt, Jacobus Pfisterer and Jalid Sehouli

J Clin Oncol 26 (16): 2683-2689




Welchen Einfluss haben Klinikmerkmale auf die Prognose beim Ovarialkarzinom in Deutschland? Analyse des Zusammenhangs zwischen Klinikmerkmalen auf Therapiequalität und Ergebnisse beim Ovarialkarzinom in Deutschland.

A. du Bois, J. Rochon, C. Lamparter, J. Pfisterer für die AGO Organkommission OVAR

Zentralbl Gynakol 2005; 127: 18–30 · © J. A. Barth Verlag in Georg Thieme Verlag KG DOI 10.1055/s-2005-836290 ISSN 0044-4197




Die Therapie des fortgeschrittenen Ovarialkarzinoms in Deutschland: Welchen Einfluss hat die Teilnahme an klinischen Studien? Ergebnisse einer Umfrage der ORGANKOMMISSION OVAR der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) in der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG) und der Deutschen Krebsgesellschaft (DKG)

A. du Bois, J. Pfisterer, Lenka Kellermann, R. Kreienberg

Geburtsh Frauenheilk 2001; 61: 863-871 © Thieme Verlag Stuttgart - New York - ISSN 0016-5751




QS-OVAR 2001

Das Qualitätssicherungsprogramm der AGO Organkommission OVAR (QS-OVAR): Versorgungsstruktur und Realität in Deutschland 2001

Analyse der Versorgungsstruktur und Qualität der Therapie des Ovarialkarzinoms in Deutschland. Untersuchung inwieweit die Therapieleitlinien umgesetzt werden, sowie Beschreibung von Prognosefaktoren.

A. du Bois, J. Rochon, C. Lamparter, J. Pfisterer

Zentralbl Gynakol 2005; 127: 9–17 · © J. A. Barth Verlag in Georg Thieme Verlag KG DOI 10.1055/s-2005-836289 ISSN 0044-4197




AGO-OVAR 3/QoL

Randomized Study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group Comparing Quality of Life in Patients With Ovarian Cancer Treated With Cisplatin/Paclitaxel Versus Carboplatin/Paclitaxel

Elfriede R. Greimel, Vesna Bjelic-Radisic, Jacobus Pfisterer, Felix Hilpert, Fedor Daghofer and Andreas du Bois

J Clin Oncol 24 (4): 579-586




AGO-OVAR 3 / Her-2/neu

Prognostic Value of Human Epidermal Growth Factor Receptor 2 (Her-2)/neu in Patients With Advanced Ovarian Cancer Treated With Platinum/Paclitaxel as First Line Chemotherapy. A Retrospective Evaluation of the AGO-OVAR 3 Trial by the AGO-OVAR Germany

Pfisterer J, du Bois A, Bentz EK, Kommoss F, Harter P, Huober J, Schmalfeldt B, Burchardi N, Arnold N, Hilpert F

Int J Gynecol Cancer 2009; 19:109-115





AGO-OVAR 14

Non-enrollment of ovarian cancer patients in clinical trials: Reasons and Backgrounds

Harter P, du Bois A, Schade-Brittinger C, Burges A, Wollschlaeger K, Gropp M, Schmalfeldt B, Huober J, Staehle A, Pfisterer J for the Study Coordination Group of the AGO-OVAR

Ann Oncol 16: 1801-1805, 2005




Neurotox

Neuroprotection with amifostine in the 1st-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy - a double-blind, placebo-controlled, randomized phase II-study from the AGO Ovarian Cancer Study Group

Hilpert F, Stähle A, Tomé O, Burges A, Rossner D, Späthe K, Heilmann V, Richter B and du Bois A for the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) ovarian cancer study group

Support Care Cancer 2005 Oct; 13(10): 797-805




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